Showing posts with label remdesivir. Show all posts
Showing posts with label remdesivir. Show all posts

Saturday, November 21, 2020

Remdesivir discouraged by WHO

On Thursday, a WHO review panel issued new guidelines recommending against the use of remdesivir for COVID-19 — even though the medicine is one of the few to win regulatory approval as a treatment for the disease.

After a clinical trial in April showed that remdesivir sped up the recovery of people with severe cases of the disease, the U.S. snapped up millions of vials of the drug from its manufacturer Gilead Sciences. Over the summer, European regulators rapidly signed off on the product, leading to nations around the world signing purchase agreements for the drug. And last month, the U.S. Food and Drug administration also signed off.

Now the WHO says remdesivir doesn't do much of anything to improve the health of people hospitalized with COVID-19.

[...]

Remdesivir gained even more prominence in October when it was given to President Donald Trump as part of his treatment after he contracted the virus.

The WHO panel says it's possible there may be some benefit from the drug. But its relatively high cost along with the risks posed by giving it intravenously led them to recommend against using it.

  NPR
But, hey...we've got the world's supply.
The retail price of remdesivir in the U.S. was set by Gilead at $520 a dose. A typical treatment course requiring six or more doses costs thousands of dollars per patient.

[...]

On Thursday, Gilead issued a statement saying it was disappointed in the WHO's decision. The pharmaceutical company and other advocates of remdesivir point to a National Institutes of Health study from April that showed the drug cut the recovery time for patients with severe cases of the disease by five days.

[...]

"When WHO guidelines are made, it involves different values that are much broader than the things considered by the FDA, which weighs very heavily the clinical outcome data."

Those broader considerations that the WHO is considering include the cost of remdesivir, the complexity of administering it in a medical setting, the potential risks giving it as an infusion — and weighing that against the potential benefits. Smith says the FDA, on the other hand, is looking primarily at clinical improvement from using the drug: whether patients' symptoms improve, whether fewer people die, for example.

"This is really consistent with how we think about health care in the U.S.," she says, "which is that we're willing to spend a lot of money on health care for a very small improvement. And that is not the model everywhere in the world."
Here, we're more than willing to enrich insurance companies.

Thursday, April 23, 2020

He doesn't need to be impeached again...

He needs to be straightjacketed.


"I see the disinfectant that knocks it out in a minute, one minute. And is there a way we can do something like that by injection inside or almost a cleaning," the president said during the briefing, speaking to his health officials.

"As you see it gets in the lungs, it does a tremendous number on the lungs, so it would be interesting to check that."

  MSN
He knows a lot about medicine. People can't believe how much he knows. They're always asking him how he knows so much.
Bill Bryan, a Department of Homeland Security official who leads the department's Science and Technology [...] under questioning from reporters, later said federal laboratories are not considering such a treatment option.

He added that heat and humidity alone wouldn't kill the virus if people don't continue to social distance.

Later asked to clarify, Bryan said this is not the kind of work he does in his lab, before the Trump jumped in and added, "maybe it works, maybe it doesn't work."


The look on Bryan's face.

Also, another drug the idiot touted has failed.







He's doing exactly what he thought you wanted him to do, you fucking jackass.

...but hey, do what you want...you will anyway.



UPDATE:


UPDATE:


The only people who need to be told that are MAGAts, Joe, and they're not listening to YOU, so you don't have to say it.

UPDATE:


Saturday, March 21, 2020

How to make a mint off a pandemic

The media has mostly focused on individuals who have taken advantage of the market for now-scarce medical and hygiene supplies to hoard masks and hand sanitizer and resell them at higher prices. But the largest voices in the health care industry stand to gain from billions of dollars in emergency spending on the pandemic, as do the bankers and investors who invest in health care companies.

[...]

In recent weeks, investment bankers have pressed health care companies on the front lines of fighting the novel coronavirus, including drug firms developing experimental treatments and medical supply firms, to consider ways that they can profit from the crisis.

[...]

In some cases, bankers received sharp rebukes from health care executives; in others, executives joked about using the attention on Covid-19 to dodge public pressure on the opioid crisis.

Gilead Sciences, the company producing remdesivir, the most promising drug to treat Covid-19 symptoms, is one such firm facing investor pressure.

Remdesivir is an antiviral that began development as a treatment for dengue, West Nile virus, and Zika, as well as MERS and SARS. The World Health Organization has said there is “only one drug right now that we think may have real efficacy in treating coronavirus symptoms” — namely, remdesivir.

The drug, though developed in partnership with the University of Alabama through a grant from the federal government’s National Institutes of Health, is patented by Gilead Sciences, a major pharmaceutical company based in California.

  The Intercept
Over the years there have been numerous drugs and other invetions either funded by the government or actually developed by the government and given to private companies to manufacture. They profit. We pay.
The firm has faced sharp criticism in the past for its pricing practices. It previously charged $84,000 for a yearlong supply of its hepatitis C treatment, which was also developed with government research support. Remdesivir is estimated to produce a one-time revenue of $2.5 billion.

[...]

Johanna Mercier, executive vice president of Gilead, noted that the company is currently donating products and “manufacturing at risk and increasing our capacity” to do its best to find a solution to the pandemic. The company at the moment is focused, she said, primarily on “patient access” and “government access” for remdesivir.

“Commercial opportunity,” Mercier added, “might come if this becomes a seasonal disease or stockpiling comes into play, but that’s much later down the line.”
Sure. Is Gilead a corporation? Does it have a board of directors?
Steve Collis, president and chief executive of AmerisourceBergen, noted that his company has been actively involved in efforts to push back against political demands to limit the price of pharmaceutical products.

Collis said that he was recently at a dinner with other pharmaceutical firms involved with developing “vaccines for the coronavirus” and was reminded that the U.S. firms, operating under limited drug price intervention, were among the industry leaders — a claim that has been disputed by experts who note that lack of regulation in the drug industry has led to few investments in viral treatments, which are seen as less lucrative. Leading firms developing a vaccine for Covid-19 are based in Germany, China, and Japan, countries with high levels of government influence in the pharmaceutical industry.

[...]

“We can’t say too much,” Collis responded. But the executive hinted that his company is using its crucial role in responding to the pandemic crisis as leverage in [opioid lawsuits] settlement negotiations. “I would say that this crisis, the coronavirus crisis, actually highlights a lot of what we’ve been saying, how important it is for us to be very strong financial companies and to have strong cash flow ability to invest in our business and to continue to grow our business and our relationship with our customers,” Collis said.

[...]

MARKET PRESSURE has encouraged large health care firms to spend billions of dollars on stock buybacks and lobbying, rather than research and development.

[...]

In Spain, the government seized control of private health care providers, including privately run hospitals, to manage the demand for treatment for patients with Covid-19.

But pharmaceutical interests in the U.S. have a large degree of political power. Health and Human Services Secretary Alex Azar previously served as president of the U.S. division of drug giant Eli Lilly and on the board of the Biotechnology Innovation Organization, a drug lobby group.

During a congressional hearing last month, Azar rejected the notion that any vaccine or treatment for Covid-19 should be set at an affordable price. “We would want to ensure that we work to make it affordable, but we can’t control that price because we need the private sector to invest,” said Azar. “The priority is to get vaccines and therapeutics. Price controls won’t get us there.”
Because of human scum like him and other corporate and finance industry assholes.
The initial $8.3 billion coronavirus spending bill passed in early March to provide financial support for research into vaccines and other drug treatments contained a provision that prevents the government from delaying the introduction of any new pharmaceutical to address the crisis over affordability concerns. The legislative text was shaped, according to reports, by industry lobbyists.
Always is.
As The Intercept previously reported, Joe Grogan, a key White House domestic policy adviser now serving on Donald Trump’s Coronavirus Task Force, previously served as a lobbyist for Gilead Sciences.

[...]

Drug companies often eschew vaccine development because of the limited profit potential for a one-time treatment. Testing kit companies and other medical supply firms have few market incentives for domestic production, especially scaling up an entire factory for short-term use.
Free market capitalism at its finest. This is why we need governments.
Last Friday, [Rep. Andy Levin, D-Mich.] circulated a letter signed by other House Democrats that called for the government to take charge in producing ventilators, N95 respirators, and other critical supplies facing shortages.
I bet it got exactly zero Republican signatures.
The once inconceivable policy was endorsed on Wednesday when Trump unveiled a plan to invoke the Defense Production Act to compel private firms to produce needed supplies during the crisis. The law, notably, allows the president to set a price ceiling for critical goods used in an emergency.
He essentially said he COULD do that, and that he didn't think it was necessary.


...but hey, do what you want...you will anyway.